DBCO Click Reagents

DBCO (dibenzocyclooctyne) is one of CBP’s most popular azide-reactive click chemistry reagents that can react rapidly and efficiently with an azide group without the use of copper catalysts. This is a bioorthogonal labeling molecule – can occur within living systems – containing a highly strained cyclooctyne group, reacting rapidly through SPAAC (strain-promoted azide-alkyne cycloaddition), forming a stable triazole linkage with high specificity. As a result, DBCO reagents are one of the most widely used click chemistry reagents for labeling proteins, nucleic acids, cells, and other biomolecules under physiological conditions without metal toxicity.