Description
Synonyms: Carbonylacrylic(NBE)-DSPE, DSPE Carbonylacrylic(CBA), PE-Carbonylacrylic(CBA), 1,2-distearoyl-sn-glycero-3-phosphoethanolamide-Carbonylacrylic(CBA)
Carbonylacrylic DSPE is a lipid conjugate in which the phospholipid DSPE is functionalized with a carbonylacrylic (CBA) group, providing selective bioconjugation with thiols. DSPE (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine) is a saturated phospholipid that serves as a core structural building block in liposomes, lipid nanoparticles, micelles, and other lipid-based drug delivery systems. Carbonylacrylic is a thiol-reactive Michael acceptor that reacts rapidly and selectively with cysteine thiols (-SH) under physiological conditions. Unlike maleimides, carbonylacrylic conjugates generally form more stable thioether linkages, with improved resistance to hydrolysis and thiol exchange.
Product Specifications:
- Form: Solid;
- Color: Light yellow;
- Lipid type: C18 PE (Phosphoethanolamine);
- Solubility: Soluble in ethanol;
- Purity: >98%;
Storage Conditions:
- Store at -20 °C; Protect from light.
